Nature Medicine Jastreboff, A
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Recent studies have demonstrated that spermidine effectively inhibits the phosphorylation of signal transducer and activator of transcription 1 (STAT1) by upregulating protein tyrosine phosphatase non-receptor 2 (PTPN2), thereby promoting macrophage polarization toward the anti-inflammatory M2 phenotype and suppressing excessive inflammatory responses
[2] Severe drowsiness or unusual fatigue feeling out of it or excessively sleepy beyond normal tiredness
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