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The tissue under the tongue is highly vascular, with direct access to systemic circulation

Koi states 99 percent or higher purity, HPLC verification with LC-MS confirmation, and an independent ISO 17025 lab that re-runs every batch

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These ROS oxidize PUFAs in cell membranes into lipid peroxides (PUFA-OOH), thereby destroying cell membrane structural stability, attacking cellular DNA and proteins, and causing ferroptosis

In practice this means three differences

With increasing CSA-13 concentration and increasing incubation time in blood, we observe a decrease in CFU/mL of this bacterium, but we assume that the extension of incubation time may correlate with a reduction in the therapeutic dose of CSA-13