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Postmortem results show increased TLR4 protein expression in the prefrontal cortex of schizophrenia patients (152), which is associated with activation of the MyD88 and NF-B pathways (156)

Markesbery WR, Lovell MA

In agreement, ASMase knockout mice exhibited enhanced hepatotoxicity and liver damage after APAP overdose, while hepatocytes challenged with U18666A, which induces the accumulation of cholesterol in lysosomes, sensitized hepatocytes to APAP-mediated cell death

Clin Neurophysiol

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