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This highlighted the importance of implementing an antioxidant system that could mitigate the negative charge imbalance caused by overexpression of ROS

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Tu J, Zhang B, Fang G, Chang W, Zhao Y

Masuo K, Mikami H, Ogihara T, Tuck ML

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158 Available findings have allowed us to speculate that the biological activities of oxidized AAT may depend on the magnitude of AAT oxidation, in a manner similar to that discussed for HSA (Figure 3)