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People who are more involved in their treatment decisions and have a better understanding of the treatment strategy are more likely to be satisfied with their healthcare [121], while a lack of shared decision-making between patient and prescriber can affect patient satisfaction and may result in non-adherence [122]

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The Cas9/sgRNA ribonucleoprotein complex, while the most responsive mode of action, has a low off-target rate and low toxicity, but the large size of the complex complicates delivery

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