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More serious but less common safety considerations observed across this drug class include a potential risk of pancreatitis, gallbladder-related conditions (such as gallstones/cholelithiasis), and based on animal studies a theoretical concern regarding thyroid C-cell tumours, though this has not been confirmed in human trials

Hogg JC

Antioxid Redox Signal 6:6374, PMID: 14713336 Johnson WM, Wilson-Delfosse AL, Mieyal JJ (2012) Dysregulation of glutathione homeostasis in neurodegenerative diseases

Oocytes injected with pure water instead of RNA, which were incubated in the same way as oocytes with RNA, served as negative controls

AlKhafaji, N