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In fact, studies have shown that every pound of weight loss can reduce knee joint load by roughly four pounds during movement

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15 I and II, Thieme, Stuttgart, 1987

What to keep in mind: Some people find the thigh slightly more sensitive than the abdomen, especially in the beginning

B12 and related B vitamins are worth special attention because many compounded GLP-1 formulations include B12 with semaglutide or B12 with tirzepatide precisely because reduced food intake lowers B vitamin status