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doi: 10.1038/s41467-018-08033-9 3 KuoYYLinHPHuoCSuLCYangJHsiaoPHet al

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Research shows that CML cells with the BCR-ABL-T315I mutation treated with AKI603 display features typical of senescent cells, such as increased SA--Gal activity, altered morphology, elevated levels of p53, p21, p27, and p16, as well as SASP secretion [79]