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Severe symptoms can begin to develop, and those symptoms are the things that lead physicians and patients to make that decision to consider either a kidney transplant or kidney replacement therapies like dialysis

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Adding supplemental vitamin C in the form of ascorbic acid, the equivalent form of vitamin C found naturally in foods, will increase blood levels further, but natural absorption of vitamin C above the intake of about 200 mg decreases sharply with increasing doses by as much as 50%

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