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3 Rubber band ligation Ligating the apex of the hemorrhoidal cushion stops the arterial flow and causes the hem-orrhoidal tissue to undergo necrosis (Figure 2)

During this rupture, pro-inflammatory cytokines such as IL-1 and IL-18 are released, triggering local or systemic inflammatory responses

Another associated protein, nerve growth factor 1-A binding protein-2 (NAB2), which acts as a co-activator for EGR-1, has also been implicated

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Tier 3 on the Kaiser formulary

Boosting Collagen Production : Collagen is a critical component of connective tissues, such as tendons and ligaments