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TXNRD1 has emerged as a selective vulnerability in KRAS -wild-type and KRAS inhibitor-resistant tumors, where its blockade induces ferroptosis through combined GSH depletion and iron overload 117

It is quantitatively the most important donor of ammonia in kidney and liver, and plays a role in maintaining the acid-base balance of body fluids

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If the treatment had continued to 72 weeks, the gap could have narrowed substantially

Labs may include CBC/CMP, lipids, A1C

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