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As it was previously demonstrated that lysine lactylation was induced by neural excitation, a key molecular mechanism for the development of epilepsy [96], with the detailed results showing the positive association of increase of lysine lactylation and the expression of the immediate-early gene marker of neuronal activity c-Fos [97], it is hypothesized that histone delactylation by HDAC1-3 may inhibit the development of epilepsy and prevent seizures

doi: 10.1046/j.1365-2826.1999.00364.x 129 CabralesAGilJFernndezEValenzuelaCHernndezFGarcaIet al

101 Several studies indicate that nicotine exerts neuroprotective effects via activation of nAChRs

This vitamin reduces cell damage and removes toxins from the liver