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Rotate to a completely different anatomical region (if injecting deltoids, switch to vastus lateralis or abdominals) and reduce dose by 50% for the next 3 injections

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Related to this, it has also been described in vitro that GLO2, using SLG as a substrate, can induce the S-glutathionylation of metabolic enzymes of different cellular compartmentalization, in particular malate dehydrogenase, cytochrome b, and complex I from the mitochondria [12,35,50,51], although the relevance of this observations rests to be determined in vivo

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Immune response becomes less efficient