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Bright field images show structurally healthy neurons after transfection to rule out overt cellular damage

2025;122(1):e2422321121

Sirtuins are known to influence the body's response to oxidative stress and inflammation, and their dysregulation could lead to increased oxidative damage and reduced ATP production (Sara et al., 2021), further exacerbating symptoms of fatigue and metabolic dysfunction

Centenarians have plasma MOTS-c levels resembling those of people decades younger, suggesting preserved mitochondrial signaling is a feature of exceptional aging

These observations underscore that GSH availability is a critical determinant of the oxidative threshold beyond which lipid peroxidation becomes self-propagating and ferroptotic death ensues