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Ipamorelin selectively releases growth hormone without causing cortisol or prolactin spikes that occur with GHRP-2 and GHRP-6

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The loss of PTEN promotes activation of the PI3K/AKT pathway, and its downstream mTOR protein activates eIF-4E and consequently promotes the translation of HIF-1 protein 50,51 ( Figure 3D )

doi:10.1016/j.ymgme.2009.04.005