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Perspective and future directions Development of the first GLP-1R/ GcgR co-agonists has prompted the search for novel multi-agonists of differentiated mechanisms that offer unprecedented potential in the treatment of obesity

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Systemic medical treatment is recommended in severe case with corticosteroids, azathioprine, cyclophosphamides, cyclosporine A, interferon-alpha, and anti-tumor necrosis factor alpha agents [107]