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These results demonstrated that tirzepatide 10 and 15 mg had the lowest NNT, where an additional patient achieving the 5% weight reduction threshold would be observed if treating an additional 1.47 and 1.46 patients with tirzepatide 10 and 15 mg, respectively, rather than placebo

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Microdose-Specific Considerations Lower starting dose may reduce the severity or frequency of gastrointestinal side effects during initiation Your provider will titrate the dose upward based on your response and tolerance All boxed warnings and contraindications still apply regardless of dose References Semaglutide ODT Pills (Compounded) Semaglutide Oral Dissolving Tablets (ODT) provide the same active ingredient as injectable semaglutide in a needle-free oral form that dissolves under the tongue

Participants received low-dose subcutaneous semaglutide 1 mg vs placebo for 24 weeks to understand its effects on body composition

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