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Metformin use increases the relative abundance of A
These data suggested that gut microbiotamediated PAR2 activation, which is attenuated in PAR2-R38E mice (21, 22), contributed to the alteration in postprandial homeostatic GLP-1 levels
123 Curiously, glucagon has been shown to induce satiety in both human and rat studies, 124 which is surprising as this hormone is released into circulation due to a decrease in plasma levels of nutrients, and thereby it induces the breakdown of stored nutrients so that tissues throughout the body have fuel to generate ATP when needed
Proc Natl Acad Sci U S A 2000, 97: 5071-5076
Fatemi, S
doi: 10.1016/j.arr.2024.102286 107 ImanishiTSaitoT
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