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Potential Risks and Considerations While generally considered safe for most people, semaglutide may not be suitable for everyone

A prescriber experienced in GLP-1 therapy recognises this pattern and guides metabolic adaptation management rather than reflexively increasing medication

Ongoing support includes telehealth follow-ups to assess side effects, adjust doses, and track weight and health markers over time

In primary SS renal tubulointerstitial injury, CD163-positive cells and high expression of HIF-1 were reported, where HIF-1 could promote macrophage polarization and participate in renal tubular injury, and early intervention to release HIF-1 could improve renal function in patients (197)

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Histological assessment and scoring were performed by a pathologist blinded to the study conditions