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Age-related considerations Clinical trials included adults across a range of ages, but specific data on elderly populations is limited

The nucleus localization significantly increases the effectiveness of DNAzyme therapy

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Acknowledgements We would like to thank Ido Zur, Evyatar Shaked, and Benjamin Stampfer for technical assistance with some of the molecular biology experiments and Ishai Sher, Gal Ambar, Genia Brodsky, and Sahlav Bar for assistance with graphical design