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doi:10.1016/S0090-9556(24)15356-1

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Disruption of gut mucosal integrity and barrier dysfunction results in increased permeability to allergens, toxins and pathogens, leading to immunological stress response and inflammation (28, 34)

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Moreover, a subset of single gene mutations associated with ASD are also responsible for other neurodevelopmental disorders, including fragile X mental retardation syndrome 1 (FMR1) in fragile X syndrome, tuberous sclerosis 1(TSC1) in tuberous sclerosis, and methyl-CpG binding protein 2 (MECP2) in Rett syndrome [11]

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