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The direct administration of GLP-1 and Ex4 into the median eminence, at the level of the secretory terminals of GnRH neurons, stimulated the GnRH secretion with concomitant stimulation of LH secretion, at least in the ovine species

Whilst GLP-1 RA usage is effective at driving weight loss, the magnitude varies depending on factors such as the type of GLP-1 RA used, treatment duration, and the individual

(2025) 13:e70273

Understanding the differences is essential before choosing one

In addition, the metal-peptide complex is sensitive, and rapid clearance is described after dermal injection

Biological plausibility does not equal therapeutic validation