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To view the other articles in this section visit Abbreviations MPST 3mercaptopyruvate sulfurtransferase ATF4 activating transcription factor 4 CDO cysteine dioxygenase CSE cystathionine lyase FXR farnesoid X receptor GH growth hormone GPABR1 GPCR for secondary bile acids H 2 S hydrogen sulfide HD Huntington's disease HO2 haem oxygenase 2 Keap1 kelchlike ECHassociated protein 1 mHtt mutant huntingtin NMDA Nmethyl Daspartate Nrf2 nuclear factor (erythroidderived 2)like 2 PLP pyridoxal 5phosphate SAM Sadenosylmethionine SP1 specificity protein 1 Introduction The transsulfuration pathway plays a central role in sulfur metabolism and redox regulation in cells