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McNelis, J

That pattern is often called PTLDS, and the cause is not fully settled

And yet

A variety of compounds, such as daurisoline-d4, 242 trilobatin, 243 genistein, 244 puerarin, 245 and icariin, 246 have been shown to regulate intestinal homeostasis and delay aging

J Mol Struct 15:6677 Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN (2002) Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress