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When administered into the brain circulation and cerebrospinal fluid of mice, DSIP showed a significant, dose-dependent reduction in pain response in the tail-pinch and hot-plate tests

The injectable form of semaglutide, marketed under the brand name Ozempic, is administered once weekly via subcutaneous injection

Annals of Gastroenterology

[DOI] [PubMed] [Google Scholar] 105.Indirect comparison of glucagon like peptide-1 receptor agonists regarding cardiovascular safety and mortality in patients with type 2 diabetes mellitus: network meta-analysis

A significant portion of participants reported ongoing use of preventative migraine medications, which may have influenced their responsiveness to CGRP infusion