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The evidence-based first-line strategy for lean mass preservation during caloric deficit is resistance training combined with protein-adequate nutrition

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GLP-1 improves mitochondrial function via regulation of autophagy, inhibits myocardial apoptosis, and optimizes cardiac energy metabolism [41, 42]

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The amplitude of low-frequency fluctuation (ALFF) is a measure of low-frequency signals in the brain, which correlates with the strength of local neural activity [45]