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Ohio State Health & Discovery

The FDA is in a public comment period - closing June 29, 2026 - on a proposal to formally exclude semaglutide and tirzepatide from the 503B Bulk Drug Substances List, a move that would permanently close large-scale compounding pathways for these active ingredients even in a future shortage

This concept that we can stop this medicine to do something that we know isnt good for us, it sets us up for failure in the long run, he says

Weight regain is common after discontinuing weight loss medications, particularly without sustained lifestyle changes

It takes roughly 5 weeks for the drug to leave your body completely

Core-focused strength training (planks, leg raises, cable crunches) builds the abdominal muscle structure that supports skin from underneath