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Clinical trials show modest reductions in total cholesterol, LDL-C, and triglycerides correlating with degree of weight loss achieved

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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

However, considering that the safety and tolerability profile of oral semaglutide in PIONEER 12 was consistent with that of the global PIONEER trials and with the safety profile of the GLP-1RA drug class, it is reasonable to assume that long-term safety in this population may be consistent with that seen in the long-term global trials