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This suppression is mediated through multiple mechanisms: Paracrine Regulation (Somatostatin): GLP-1 receptors are highly expressed on pancreatic -cells

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Ji et al., 2018)

Experimental Biology Med (Maywood NJ)

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GLP-1 Mechanism in Menopause: Appetite, Metabolism, and Energy Balance GLP-1 agonists suppress orexigenic (hunger-promoting) neurons and enhance satiety signals, offsetting the appetite dysregulation that accompanies estrogen decline