Originally developed to treat neurodegenerative conditions like Parkinsons and Alzheimers, this compound showed a surprising side effect during early clinical trials: rapid and sustained weight loss
After binding with PERK, TMAO selectively activates PERK-mediated UPR, thereby promoting metabolic dysfunction ( Of note, TMAO in the pathogenesis of Alzheimers disease (AD) indicated that PERK is not the only mechanism by which TMAO induces UPR
Iron is involved in thyroid hormone synthesis, and the omega-3 fatty acids EPA and DHA play a role in insulin sensitivity and appetite regulation
Acta 1843 , 20792088 (2014)
With increasing global obesity rates, finding effective weight management solutions has never been more critical
Rossing P, Tuttle KR, Mosenzon O, et al