Advantages: Continuous appetite suppression Prevents weight regain during transition Preferred by patients with history of rapid rebound eating Disadvantages: Higher nausea and vomiting risk (estimated 35% vs 22% in first 2 weeks) Overlapping GLP-1 activation may transiently worsen gastroparesis symptoms Difficult to distinguish semaglutide vs tirzepatide side effects during overlap window Clinical data supporting overlap: a 2024 case series (Garvey et al., Journal of Clinical Endocrinology & Metabolism) described 89 patients who used 3-day overlap
10.1016/j.ejim.2014.03.005
700% increase in GLP-1 use among adults without diabetes between 2019 and 2023
Know your numbers, like your cholesterol, A1C, and bone density
Besides slowing stomach emptying, increasing feelings of fullness, and reducing appetite, people also report that these medications reduce "food noise"a term that has become widely used in recent years to describe the constant mental chatter about food
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