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The timepoint chosen (when drug-tolerant cells are emerging after treatment) probably contributes to this effect, and later timepoints (when cells perhaps enter senescence or other more terminally arrested states) are more likely to reflect the expected gene expression patterns

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In contrast, metabolites connecting multiple pathways, such as DHAP, common to both the PPP and glycolysis, and OAA, common to the both TCA and glycolysis, correlated with SLEDAI, BILAG, and FAS scores, suggesting that increased flux among these pathways are involved in disease activity

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