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The model quantifies mortality and morbidity improvements by calendar year, sex, and age directly attributed to the uptake of these medications for controlling weight in obese populations and for managing diabetes

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Most GLP-1 protocols start low and titrate over 48 weeks, which slows fat mobilization compared to rapid dosing

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The running buffer was HBS EP+ buffer (10 mM Hepes pH 7.4, 150 mM NaCl, 3 mM EDTA and 0.05% (v/v) SurfactantP20) containing 0.1% DMSO

The main analysis of the primary endpoint was performed as an intention-to-treat analysis including all patients (full analysis set)