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The persistent inflammatory response interacts with the central nervous system, resulting in chronic pain (5)

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Shauna Levy of the Tulane Weight Loss Center noted that strict timing requirements could impact real-world results

Lesions to the brainstemhypothalamic pathway attenuate GLP-1induced satiation in rats, indicating the importance of central regions mediating the effect of systemic GLP-1 (73)

A prior late-stage trial published in December showed the drug helped obese or overweight patients with one or more comorbidities, but not type-2 diabetes, lower their weight by 22.7% after 68 weeks, also below the 25% expected

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