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While knee OA has traditionally been considered a degenerative disease, advancements in regenerative medicine are breaking new ground, halting and even reversing cartilage erosion, and giving new hope to knee OA sufferers

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In addition, increased permeability of both capillaries and the BBB is observed in the ischemic core, the penumbra, and other areas, resulting in perivascular and perineuronal edema

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