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Tirzepatide (Mounjaro, Zepbound) Tirzepatide targets both GLP-1 and GIP receptors, producing greater average weight loss than semaglutide in head-to-head trials, typically 20 to 25 percent of body weight

One key difference is that the doses used for weight loss are higher, which allows it to work on the brains receptors

But the human data gap is real

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2014 Nov 20;9(11):e113366

Semaglutide injections remain in the bloodstream for approximately one to two weeks, while tirzepatide persists slightly longer due to its extended half-life