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Why its helpful : Improves digestion and toxin clearance through the bile

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They are synthesised in excess during untreated (or inadequately treated) type 1 diabetes mellitus

For instance, while hyperkalemia risk is increased with MRAs and RAAS inhibitors, [6, 17, 18, 20] addition of an SGLT2i to the combination as part of a pillar approach may decrease the occurrence of hyperkalemia events with MRAs [34, 45]

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Slower titration reduces both the severity and duration of side effects