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These may be temporary and resolve without any medication changes
The inner photoreceptor matrix (IPM) situated between RPE and photoreceptor cells has previously been shown to have IGF-1 immunoreactivity [36] and also contains high levels of IGF-1 binding protein (IGFBP), which binds IGF-1 and regulates its availability [36]
After 48 h, their viability was evaluated as well as changes in topography and ultrastructure
To mitigate this, we've found that the most effective strategy is to administer the dose shortly before the subject's sleep cycle
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