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Microbiome depletion : Antibiotics, poor diet or stress can wipe out beneficial gut flora, which are protective against dysbiosis and overgrowth, and support normal gut functioning

Intratumoral injection has the limitation of accessible tumors and is practically difficult in deep-seated or metastatic cases

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Both tests came back negative: AOD9604 did not cause mutations in bacteria and did not damage chromosomes in mammalian cells

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The risk of significant microbial growth is too high, even with the preservative