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57 In this paradigm, LPSa potent Tolllike receptor 4 (TLR4) agonistis administered directly into the lateral ventricle, eliciting a controlled neuroimmune response characterized by microglial and astrocytic activation, elevated cytokine production, and neuronal loss, particularly within the hippocampus

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It is far more bioavailable, with an increase from 4-6% to 60-80%

Shang R, Sun Z, Li H (July 2014)

Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione S-transferases