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In the local anesthesia study, rats were euthanized at 4 and 14 days following the administration of free tetracaine, prodrug 7a, or the combination treatment (7a + 6b), and the injected hind footpads were harvested for analysis

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There was no significant difference in GFAP percentage area stained with 9.2 1.6%, 8.8 2.2% and 8.8 2.0% area coverage for vehicle dosed, 25 nmol/kg and 75 nmol/kg liraglutide dosed respectively ( P = 0.7824, one-way ANOVA) (Fig