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Higher investigational doses (25mg and 50mg) in the PIONEER PLUS trial showed weight reductions of approximately 10% body weight, approaching levels seen with injectable weight-loss medications

A two-tailed unpaired t -test was used to compare the means of two independent groups

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Methods Animal and cell models of PH were established using monocrotaline (MCT) and platelet-derived growth factor-BB (PDGF-BB)