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As oxidative stress increases, glutathione is used as an antioxidant, and active GSH gets depleted

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Oxid Med Cell Longev 2013, 972913.CrossRefGoogle ScholarPubMed

Thus the dose, timing, and disease-specific inflammatory response are important pharmacological considerations with GSH treatment ( In addition to being a therapeutic target, oxidative stress has been shown to decrease the GSH:GSSG ratio which has proven useful as a clinically accessible, pharmacodynamic biomarker of immune redox tone for conditions such as malignancy (Zitka et al., 2012)

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