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This narrative review aims to synthesize current evidence on the physiological and therapeutic relevance of GLP-1 signaling in sepsis, highlight mechanistic insights from preclinical studies, and assess the translational potential of GLP-1RAs in modulating systemic inflammation, metabolic dysregulation, and organ dysfunction in septic states

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For patients who have had a cardiovascular event and heart failure, SGLT2 inhibitors are recommended as first-line treatment, GLP-1 RAs or metformin as second-line treatment, and DPP4 inhibitors, acarbose, or insulin as third-line treatment [5]

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