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Bicyclol reduces the activation of NF-B and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-B pathway, and prevents ferroptosis in acute liver injury

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Conversely, breast cancer cells produce IL-6, which activates the JAK2/STAT3 axis, inducing TAMs to secrete TGF-1, thereby forming a positive feedback loop that ultimately facilitates malignant tumor progression [121]

This cascade ultimately contributes to neurodegenerative processes