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Notably, from the perspective of therapeutic strategies, precise modulation targeting palmitoylation modification of key functional proteins in specific tissues may exhibit more significant clinical translational value than relying solely on the tissue distribution profile of ZDHHC enzymes

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Rather than using standard stacks, this approach tailors compound selection to individual biological needs

This pathogenic RNA sequesters proteins in the muscleblind-like (MBNL) family, resulting in partial loss of MBNL protein function 6

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HSPs and autophagy: a synergistic relationship HSPs, particularly HSP70 and HSP90, play a pivotal role in protein folding and refolding, preventing the aggregation of misfolded proteins