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Oncoscience 1 , 665673 (2014)

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Pentoxifylline, a compound with antioxidant effects, reduces proteinuria and albuminuria in diabetic kidney disease in advanced stages of CKD through non-specific inhibition of phosphodiesterases, enzymes that have been widely implicated in the progression of kidney diseases

The compound does not care about muscle tissue

A fiber supplement can also help manage the constipation that sometimes accompanies tirzepatide use

Linaclotide (Linzess) activates a receptor in cells on the intestinal surface called the guanylate cyclase 2C receptor, which stimulates intestinal fluid secretion and softens the stool making it easier to pass