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This glucose-dependent mechanism makes GLP-1-based therapies safer compared to classical hypoglycemic drugs in critically ill septic patients ( 6.3 Cardioprotective role of GLP-1 Another important aspect is the cardioprotective effect of GLP-1

Post hoc analysis of LEADER data revealed a persistent increase in the overall risk of biliary tract-related events and gallbladder diseases, consistently observed across four categories: uncomplicated gallbladder stones, complicated gallbladder stones, cholecystitis with/without gallbladder stones, and biliary obstruction [34]

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The patients who get the most out of GLP-1 therapy are the ones whose physicians built the muscle-preservation framework in from the start