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Increased SIRT1 activity leads to the activation of adipose triacylglycerol lipase (ATGL), with subsequent triacylglycerol depletion of WAT [14]

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Thakker D, et al

While pancreatitis typically causes severe abdominal pain that radiates to the back, any significant internal inflammation can cause a general sense of body aching or discomfort that an individual might perceive as radiating into the lower extremities

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