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Several modifiable factors can either buffer genetic effects or amplify them

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This experience has provided additional information that shows we can both retain the financial integrity of benchmark calculations and ensure CMS can reliably and accurately assess ACO financial and quality performance while allowing for ACOs that have fewer than 5,000 beneficiaries assigned in their benchmark years to enter the program, if we implement additional safeguards that protect ACOs and the Trust Funds

Protocols can be short-term for healing or longer-term for optimization and maintenance, depending on individual needs

Document indication and rationale (especially when FDA alternatives exist)